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Long-lasting rejuvenation with collagen biostimulators

Collagen biostimulators are injectable treatments that work beyond simply restoring volume. They stimulate the skin’s natural remodelling processes and support new collagen production, gradually improving skin density, elasticity and structure.

At Dermique, we select from different types of collagen biostimulators according to the treatment area, skin quality, degree of laxity, volume loss and desired outcome. The focus is on progressive, natural-looking results that develop over time.

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Collagen biostimulators at Dermique

Sculptra®

Sculptra® is a poly-L-lactic acid (PLLA) collagen biostimulator designed to stimulate the gradual production of new collagen. It may be suitable for patients experiencing volume loss, skin laxity or reduced tissue density who are looking for progressive, natural-looking rejuvenation rather than an immediate or dramatic change.

Sculptra®

Sculptra logo

Sculptra® is a poly-L-lactic acid (PLLA) collagen biostimulator designed to stimulate the gradual production of new collagen. It may be suitable for patients experiencing volume loss, skin laxity or reduced tissue density who are looking for progressive, natural-looking rejuvenation rather than an immediate or dramatic change.

Radiesse®

Radiesse® is a calcium hydroxylapatite (CaHA)-based injectable that can provide structural support while also stimulating collagen production. Depending on the treatment approach, it may be used to improve contours, skin firmness and overall skin quality in selected areas of the face and body.

The most appropriate indication and technique are determined following individual assessment.

Radiesse®

Radiesse logo

Radiesse® is a calcium hydroxylapatite (CaHA)-based injectable that can provide structural support while also stimulating collagen production. Depending on the treatment approach, it may be used to improve contours, skin firmness and overall skin quality in selected areas of the face and body.

The most appropriate indication and technique are determined following individual assessment.

Juvelook®

Juvelook® is a hybrid injectable treatment that combines hyaluronic acid with poly-D,L-lactic acid (PDLLA) to support hydration and collagen stimulation.

It is particularly suited to improving skin quality in delicate areas, including the eye contour, where it may help address fine lines, thin skin and an overall tired appearance without the aim of creating significant volume.

Juvelook®

Juvelook logo

Juvelook® is a hybrid injectable treatment that combines hyaluronic acid with poly-D,L-lactic acid (PDLLA) to support hydration and collagen stimulation.

It is particularly suited to improving skin quality in delicate areas, including the eye contour, where it may help address fine lines, thin skin and an overall tired appearance without the aim of creating significant volume.

HArmonyCa™

HArmonyCa™ is a hybrid injectable combining hyaluronic acid with calcium hydroxylapatite (CaHA). The hyaluronic acid component provides an immediate volumising and structural effect, while CaHA supports the gradual stimulation of collagen production.

It may be suitable for selected patients seeking improved facial support, definition and skin firmness alongside progressive improvement in skin quality.

HArmonyCa™

HArmonyCa logo

HArmonyCa™ is a hybrid injectable combining hyaluronic acid with calcium hydroxylapatite (CaHA). The hyaluronic acid component provides an immediate volumising and structural effect, while CaHA supports the gradual stimulation of collagen production.

It may be suitable for selected patients seeking improved facial support, definition and skin firmness alongside progressive improvement in skin quality.

Collagen biostimulators at Dermique
What concerns can collagen biostimulators address?
Depending on the product and individual indication, collagen biostimulators may be suitable for:
  • loss of skin density and elasticity
  • skin laxity
  • volume loss
  • fine lines and deeper folds
  • photo-damaged or thinning skin
  • improving skin quality on the hands, neck and décolletage
  • patients seeking gradual, natural-looking rejuvenation
What to expect during your treatment

Before treatment, we assess the face, skin quality and the areas requiring structural support or remodelling. Product selection is an important part of the treatment plan, as different biostimulators vary in composition, tissue behaviour, injection technique and the way their results develop over time.

The selected product is precisely placed in predetermined areas according to the individual treatment plan. A local or topical anaesthetic may be used where appropriate for additional comfort.

Temporary swelling, redness, tenderness or bruising may occur following treatment.

Combining collagen biostimulators with other treatments
Collagen biostimulators can form part of a broader treatment plan when the aim is to address multiple aspects of facial ageing and skin quality — from volume and structural support to firmness, texture and hydration. The most appropriate combination and treatment sequence are determined individually according to facial anatomy, skin condition and the desired outcome.

Collagen biostimulators + hyaluronic acid fillers

Hyaluronic acid fillers can restore volume, structure and facial contours, while collagen biostimulators focus on gradually improving tissue quality and supporting collagen production. The two approaches may complement each other in selected patients with volume loss, reduced definition or changes in skin quality.

Collagen biostimulators + botulinum toxin

Botulinum toxin is used to reduce the appearance of dynamic lines by temporarily modifying targeted muscle activity, while collagen biostimulators focus on skin structure, density and firmness.

When appropriately planned, the combination can address different aspects of facial ageing while maintaining a natural-looking result.

Collagen biostimulators + Morpheus8 Burst

Morpheus8 Burst combines microneedling with radiofrequency energy to promote tissue remodelling and improve skin firmness and texture. Collagen biostimulators may complement this approach by supporting progressive collagen production and improvement in tissue quality.

The timing and sequence of the treatments are determined individually.

Collagen biostimulators + skin boosters

For dehydrated or delicate skin, skin boosters and collagen biostimulators may be incorporated into the same overall treatment plan to address different aspects of skin quality.

Skin boosters primarily focus on hydration and elasticity, while collagen biostimulators target progressive tissue remodelling and collagen production. The appropriate sequence depends on the products used and the individual condition of the skin.

Rejuvenation that evolves naturally
Personalised biostimulatory treatments focused on skin quality, structure and progressive, natural-looking results.
Frequently asked questions
What is the difference between collagen biostimulators and hyaluronic acid fillers?
Hyaluronic acid fillers are primarily used to restore volume, provide structural support or refine specific facial contours, with an effect that is often visible immediately.

Collagen biostimulators work differently. Their primary purpose is to stimulate collagen production and tissue remodelling, so improvements in skin density, firmness and structure develop progressively over time. Some hybrid biostimulatory products may also provide an immediate effect depending on their composition.
The timeline varies depending on the product used. Some treatments may provide an initial visible effect, while collagen stimulation and tissue remodelling develop progressively over the following weeks and months.

Your doctor will explain what to expect from the specific product selected as part of your treatment plan.
The recommended number of sessions varies considerably between products and depends on the treatment area, skin condition, degree of volume loss or laxity and individual goals.

Some biostimulatory treatments are performed as a course, while others may require fewer sessions. An individual protocol and any appropriate maintenance treatment will be discussed during consultation.
No. Suitability depends on the specific product, treatment area and individual medical history. Treatment may not be appropriate in the presence of active infection or inflammation in the treatment area, known hypersensitivity to product components or certain other medical conditions.

Pregnancy, breastfeeding, medications and relevant health conditions should be discussed during consultation. Treatment is performed only after an individual medical assessment confirms that it is appropriate.
Treatment is based on skin condition and individual indication rather than age alone. In younger patients, selected biostimulatory treatments may be considered for concerns such as early changes in skin quality, fine lines, texture or acne scarring.

In more mature skin, the focus may shift towards improving density, firmness, tissue quality and visible signs of photoageing or skin laxity. The appropriate product and treatment plan are always selected following individual assessment.

Atrophic scars

Atrophic scars are indented scars that most commonly appear following acne or other inflammatory conditions. They are caused by a loss of collagen and uneven skin regeneration.

Appropriate treatment methods

At Dermique, we don’t treat acne scars using just one technique. Where necessary, we combine: